PQQ benefits - Pyrroloquinoline Quinone - Mitochondrial Biogenesis

PQQ benefits and how they help the brain

Have you been looking for a supplement to combat ageing? Well PQQ may be it. Scientists found out about this compound only 50 years ago. There have been several health studies conducted about the potential benefits it provides the human body, the brain in particular.

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What is PQQ?

PQQ is like a bodyguard to a man’s brain. PQQ is the acronym for pyrroloquinoline quinone. It is a compound found naturally in breast milk, soil, and certain foods. Pyrroloquinoline quinone PQQ helps the mitochondria (the powerhouse of the cells) thrive and continue to give us good health and longevity. According to researchers, PQQ provides neuroprotection, aiding in the formation of new mitochondria cells in the brain. This is very important if you wish to fight ageing issues such as loss of cognitive abilities and decreased energy levels.

Health benefits of PQQ pyrroloquinoline quinone

Here are the 13 health benefits that PQQ may provide you.

Treats obesity

PQQ may be a feasible weight loss solution. A study using rats showed that a diet deficient of PQQ reduced their metabolism by 10 per cent. Another study conducted on obese infant mice discovered that supplementing with PQQ increased their metabolism, reduced body fat, and may prevent nonalcoholic fatty liver disease. To further validate PQQ as an effective remedy against obesity, research on humans needs to be conducted.

Relieves inflammation

Inflammation opens the floodgate to slew of health problems, including accelerated ageing and neurological problems. Chronic inflammation in the brain is common to many neurodegenerative ailments such as Alzheimer’s disease and stroke.  PQQ may be able to combat this problem. Research shows that individuals who supplement with PQQ are protected against brain inflammation. Another study conducted on animals showed that PQQ has the ability to protect against inflammation may decrease the effects of traumatic brain injuries (e.g., concussion).

Enhances brain function

One of the main benefits of this compound is how much it enhances brain functionality. It stimulates the production and release of brand-new nerve cells (called nerve growth factor) that assist in neural tasks. These nerve cells communicate with each other to ensure that organs and other bodily functions are running smoothly. Studies appear to show that PQQ improves the memory, thinking, learning, and other cognitive abilities in ageing adults. In addition, research shows that PQQ has the ability to heal and rejuvenate damaged nerve cells, particularly in the brain.

Reduces oxidative stress

Oxidative stress can cause many different diseases – cancer, brain disorders, diabetes, heart problems, and more. This happens when an imbalance between free radicals and antioxidant defense occurs; a problem worsened by aging. PQQ helps boost the production of DJ-1, a protein that supports healthy brain function. This protein fights off oxidative stress by enhancing cell function and survival. In addition, PQQ protects new nerve cells from oxidative damage. This allows these nerve cells to survive and be able to potentially form new brain cells.

May extend lifespan

This compound may be able to improve your longevity. As one gets older, the brain suffers from multiple sources of damage. As the damage accumulates over time, this usually leads to the formation of brain disorders and chronic diseases such as stroke. Supplementing with PQQ may help guard against these neurological issues, especially as one gets older. And a big reason for this is because of its support of the mitochondria. Research shows that PQQ aids in the creation of new mitochondrial content. This increases longevity as well as improve energy utilisation and protection from free radicals.

Promotes mitochondrial function

Piggybacking off the last benefit, PQQ is a big proponent of the mitochondria. It aids and supports the mitochondria by promoting new content as well as improving the function of the current mitochondria. The mitochondria are responsible for transforming the food we eat into the energy needed to power our cells. This allows our cells to perform at peak function. Aiding the mitochondria promotes longevity and reducing the onset of age-related diseases. A human study showed that supplementing with PQQ rejuvenates mitochondrial function and restore new mitochondrial numbers. The study also showed improvements in the participants’ urinary oxidant levels, an indicator that the mitochondria are performing well.

Decreases cholesterol

Cholesterol is a waxy substance that’s found in all the cells in your body. Your body needs some cholesterol to serve a lot of functions, including the creation of Vitamin D and hormones. The problem lies when a man has too much cholesterol. High cholesterol clogs up blood vessels, making the heart work harder to perform its daily tasks. Ultimately, this may lead to a heart attack and/or a stroke. PQQ may help regulate cholesterol levels. A Japanese study showed that individuals who supplemented with PQQ disodium salt lowered their bad LDL cholesterol levels.

Improves sleep, mood, and fatigue

Millions of men don’t get enough sleep on a nightly basis. Poor sleep quality is linked to a slew of chronic diseases such as stroke. In addition, a lack of sleep negatively affects your mood and causes fatigue throughout the day. PQQ may be what you need if you have had issues getting good quality sleep. A 2-month research study showed that individuals who used PQQ improved overall sleep quality. They were able to fall asleep with no issues and slept longer. Also, the subjects showed significant improvements in their mood and energy levels.

Improves memory and reasoning

The biggest issue most men face as they get older is the loss of cognitive function. According to the Alzheimer’s Association, men are at greater risk of developing age-related cognitive deficiencies that often cause memory loss and the inability to think clearly. Several studies point out how PQQ could reverse this trend. PQQ may prevent brain decline that stems from ageing. Human and animal studies demonstrate its ability to improve one’s memory and reasoning skills. The main reason for this is due to PQQ’s ability to trigger mitochondrial growth and reduce oxidative stress.

Protects your heart from stroke

According to the CDC, heart disease is the leading cause of death for both men and women. More than half of the deaths due to heart disease in 2015 were in men. PQQ may be able to curtail those statistics. An animal study showed that PQQ improves cardiac functions and reduce damages for heart attack sufferers. And these benefits can happen when PQQ is taken before or after the heart attack occurred.

Another study compared the effects of PQQ to standard heart attack medicine (metoprolol). Both reduced the size of the damaged areas and protected against further trauma. However, PQQ did a better job of reducing cellular damage. This led researchers to deem the compound as the superior medicine to protect the heart against oxidative stress. Further evidence has shown that PQQ is highly effective at supporting mitochondrial function within the heart cells.

Decreases insulin resistance

Insulin resistance interferes with our ability to effectively regulate our sugar intake. This can lead to health problems such as diabetes, metabolic syndrome, and obesity. Similar to exercise, PQQ reduces insulin resistance by boosting mitochondrial activity in muscle cells. The compound also inhibits, PTP1B, a protein that’s been shown to cause insulin resistance. (High levels of this protein is found in people suffering from breast cancer)

Improves immune health

It is widely known how essential it is to have an efficient immune system. An efficient immune system prevents the onset of chronic diseases and fights off inflammation. A study showed that mice lacking enough PQQ experienced poor immune function. In another mice study, increased intake of the compound boosted immune health. It did this by increasing levels of two vital immune regulators: CD8+ cells and lymphocytes.

PQQ is neuroprotective against Alzheimer’s disease, Parkinson’s, and cognitive injuries

One thing you definitely know by now is that PQQ is neuroprotective. This compound does a good job of protecting memory and cognitive skills. The worst diseases deriving from poor brain health is Alzheimer’s and Parkinson’s. Both diseases affect millions of people worldwide, the elderly in particular. PQQ may protect against the onset of Alzheimer’s Disease and Parkinson’s disease.

One study shows that it protects the brain against powerful toxins and proteins that are associated with these cognitive diseases. And the compound protects neurons from overstimulation, a condition called excitotoxicity. Excitotoxicity of the neurons is associated with seizures, schizophrenia, and other neurodegenerative diseases.

How to take PQQ

PQQ dosage

Here are the recommended dosage amounts for PQQ supplements:

To boost mitochondrial activity in your cells….0.075 to 0.3mg/kg per day

To decrease chronic inflammation in the average-size male….20mg per day

Food

Supplementation of PQQ is great. But to really maximise your exposure to the compound, your diet should consist of PQQ-rich natural food sources and plant-based foods. Here is a list of such foods:

Sweet Potato

Parsley

Egg Yolk

Cabbage

Natto

Papaya

Green Pepper

Carrot

Spinach

Fava Bean

Miso

Kiwi

Celery

Potato

Orange

Banana

Tomato

Green Peppers

PQQ supplement

After combing through a litany of online stores, here are five PQQ supplements that have gained a ton of favorable reviews. (Note: This is not a top five list.)

Doctor’s Best, Best PQQ, 20 mg, 30 Veggie Caps

Jarrow Formulas, Ubiquinol, QH+ PQQ, 30 Softgels

Swanson Ultra: PQQ Pyrroloquinoline Quinone

PQQ + CoQ10 – 60 Capsules – Oral Supplement for Cardiovascular and Mental Support by Dr’s Hope

PQQ 20mg (Pyrroloquinoline Quinone) 30 Vegecaps

PQQ side effects and dangers

As with any supplement, there is a likelihood of side effects. PPQ is no different. In one study, rats were given a dosage as high as 100mg/kg per day but experienced no side effects. However, some humans who took the compound experienced insomnia, mild headaches, and even energy crashes during the midday. The reason for these side effects could be that they either took too much or their body is sensitive to a direct dosage of pyrroloquinoline quinone.

Either way, it is wise to start off with a small dose (0.075mg) for at least one week. If you can handle that, feel free to slightly increase the dosage. It’s recommended that you don’t take no more than 20mg per day.

PQQ supplement may be the next best supplement for men

Protein powder and fish oils may have to make room for PQQ. This compound shows a lot of promise, especially for older men. PQQ may be the best anti-ageing supplement/nutrient that most guys don’t know about. Some who have supplemented with it felt that it immediately:

Improved their mood

Improved their focus and ability to remember things

Boosted their energy levels

Improved workout performance

And those are just the immediate benefits. Other benefits such as lower cholesterol and an improved immune system will obviously take time to manifest. Overall, pyrroloquinoline quinone is a substance that you should consider getting acquainted with as you get older.

SAMe Supplements Benefits and Use

- If you live with a condition like osteoarthritis or depression, you may already know how it can affect other aspects of your health, contributing to issues like weight gain, difficulty sleeping, and chronic pain.

One remedy said to ease depression, arthritis, and other conditions is the supplement SAMe, also known as SAM-e, ademetionine, or S-adenosylmethionine. SAMe is the synthetic form of a compound that is produced naturally in the body from methionine (an essential amino acid) and adenosine triphosphate (an energy-producing compound).

SAMe isn't found naturally in food. The body typically makes what it needs for good health, however, some disease states and low levels of methionine, folate, or vitamin B12 are believed to contribute to low levels of SAMe.

It's thought that SAMe can help promote the production of chemicals known to play a key role in a variety of processes in the body, such as mood regulation, immune function, and pain perception.

Why Do People Take SAMe Supplements?

SAMe is typically used for the following health issues:

Anxiety

Depression

Fibromyalgia

Osteoarthritis

Pain

Premenstrual syndrome (PMS)

SAMe is also said to enhance mental performance, boost liver health, slow the ageing process, and help people quit smoking.

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The Benefits: Can It Really Help?

Here's a look at some of the research on the possible benefits of SAMe.

1) Osteoarthritis: SAMe shows promise in the treatment of osteoarthritis of the knee or hip. It is said to relieve pain and have anti-inflammatory properties, and some research suggests that it may promote cartilage repair.

In a report published in the Cochrane Database of Systematic Reviews in 2009, researchers analysed four previously published clinical trials (with a total of 656 participants) and found that the use of SAMe may help reduce pain and improve function in people with osteoarthritis. Since the reviewed trials were of poor quality, however, the review's authors deemed these findings inconclusive.

2) Depression: In a research review published in the Cochrane Database of Systematic Reviews in 2016, scientists analysed eight previously published clinical trials comparing SAMe to the antidepressants imipramine, desipramine, or escitalopram, or a placebo.

SAMe was superior to a placebo when used with selective serotonin reuptake inhibitor (SSRI) antidepressants, but the evidence was considered low quality. Compared to imipramine, fewer participants experienced adverse effects when treated with an injectable form of SAMe. SAMe wasn't different from the placebo or antidepressants such as imipramine or escitalopram when used alone.

In their conclusion, the review's authors state that the use of SAMe for depression needs to be investigated further in larger and better-planned trials "given the absence of high-quality evidence and the inability to draw firm conclusions based on that evidence."

3) Fibromyalgia: In a research review published in the Journal of Complementary and Alternative Medicine in 2010, scientists looked at 70 previously published clinical trials evaluating the use of various types of complementary therapies for chronic fatigue syndrome and fibromyalgia. Along with magnesium, L-carnitine, acupuncture, and several types of meditation practice, the review's authors named SAMe among the therapies with the most potential for further research on their effectiveness against these conditions.

4) Liver Disease: SAMe may improve liver function in people with chronic liver disease, suggests a research review published in the journal PLoS One in 2015. However, in evaluating the 12 previously published clinical trials included in the review, the authors also found that SAMe may of limited benefit in the treatment of certain liver conditions such as viral hepatitis and cholestasis.

Possible Side Effects

SAMe may trigger a number of side effects, including anxiety, constipation, diarrhea, dry mouth, headache, heartburn, insomnia, gas, low blood sugar, nausea, nervousness, skin rash, and vomiting. Large amounts of SAMe may cause mania (an abnormally elevated mood). There's also some concern that the use of SAMe can trigger an allergic reaction in some people. 

If you have bipolar disorder, Lesch-Nyhan syndrome, Parkinson's disease, or other health conditions, you should only use SAMe under the supervision of your healthcare provider as it may worsen symptoms. 

It's important to note that there may be risks when combining SAMe with medication or other supplements. You shouldn't take SAMe in combination with antidepressants, cough medicine, diabetes medication, levodopa (L-dopa), L-tryptophan, medication that affects serotonin levels, St. John's wort, or other medication unless you are being monitored by a health professional. SAMe should be discontinued at least two weeks before a scheduled surgery.

The safety of SAMe in children, pregnant or nursing women, or people with kidney or liver disease hasn't been established. You can get tips on using supplements safely, but you should speak with your primary care provider before taking SAMe to discuss whether it's appropriate for you. Keep in mind that SAMe shouldn't be used as a substitute for standard treatment.

Source - VeryWell   

And now the science bit

S-Adenosyl methionine[alternative names is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM-e is produced and consumed in the liver. More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase. SAM was first discovered by Giulio Cantoni in 1952.

In bacteria, SAM-e is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis. In eukaryotic cells, SAM-e serves as a regulator of a variety of processes including DNA, tRNA, and rRNA methylation; immune response; amino acid metabolism; transsulfuration; and more. In plants, SAM-e is crucial to the biosynthesis of ethylene, an important plant hormone and signaling molecule.

SAM-e cycle

The reactions that produce, consume, and regenerate SAM-e are called the SAM-e cycle. In the first step of this cycle, the SAM-dependent methylases  that use SAM-e as a substrate produce S-adenosyl homocysteine as a product. S-Adenosyl homocysteine is a strong negative regulator of nearly all SAM-dependent methylases despite their biological diversity. This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase and the homocysteine recycled back to methionine through transfer of a methyl group from 5-methyltetrahydrofolate, by one of the two classes of methionine synthases (i.e. cobalamin-dependent or cobalamin-independent. This methionine can then be converted back to SAM-e, completing the cycle. In the rate-limiting step of the SAM cycle, MTHFR (methylenetetrahydrofolate reductase) irreversibly reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.

Radical SAM-e enzymes

A large number of iron-sulfur cluster-containing enzymes cleave SAM-e reductively to produce a 5′-deoxyadenosyl 5′-radical as an intermediate, and are called radical SAM enzymes. Most enzymes with this capability share a region of sequence homology that includes the motif CxxxCxxC or a close variant. The radical intermediate allows enzymes to perform a wide variety of unusual chemical reactions. Examples of radical SAM enzymes include spore photoproduct lyase, activases of pyruvate formate lyase and anaerobic sulfatases, lysine 2,3-aminomutase, and various enzymes of cofactor biosynthesis, peptide modification, metalloprotein cluster formation, tRNA modification, lipid metabolism, etc. Some radical SAM-e enzymes use a second SAM-e as a methyl donor. Radical SAM enzymes are much more abundant in anaerobic bacteria than in aerobic organisms. They can be found in all domains of life and are largely unexplored. A recent bioinformatics study concluded that this family of enzymes includes at least 114,000 sequences including 65 unique reactions.

Polyamine biosynthesis

Another major role of SAM-e is in polyamine biosynthesis. Here, SAM-e is decarboxylated by adenosylmethionine decarboxylase to form S-adenosylmethioninamine. This compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.

SAM-e is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and neurotransmitters that affect mood, such as epinephrine. Methyltransferases are also responsible for the addition of methyl groups to the 2′ hydroxyls of the first and second nucleotides next to the 5′ cap in messenger RNA.

As of 2012 the evidence was inconclusive as to whether SAM can mitigate the pain of osteoarthritis; clinical trials that had been conducted were too small from which to generalize. A 2016 study concluded that for major depressive disorder, "Given the absence of high-quality evidence and the inability to draw firm conclusions based on that evidence, the use of SAMe for the treatment of depression in adults should be investigated further."

The SAM-e cycle has been closely tied to the liver since 1947 because people with alcoholic cirrhosis of the liver would accumulate large amounts of methionine in their blood. While multiple lines of evidence from laboratory tests on cells and animal models suggest that SAM might be useful to treat various liver diseases, as of 2012 SAM had not been studied in any large randomized placebo-controlled clinical trials that would allow an assessment of its efficacy and safety.

Pharmacokinetics

Oral SAM achieves peak plasma concentrations three to five hours after ingestion of an enteric-coated tablet (400–1000 mg). The half-life is about 100 minutes.

Adverse effects

Gastrointestinal disorder, dyspepsia and anxiety can occur with SAM consumption. Long-term effects are unknown. SAM is a weak DNA-alkylating agent.

Another reported side effect of SAM is insomnia; therefore, the supplement is often taken in the morning. Other reports of mild side effects include lack of appetite, constipation, nausea, dry mouth, sweating, and anxiety/nervousness, but in placebo-controlled studies, these side effects occur at about the same incidence in the placebo groups.[medical citation needed]

SAM-e has recently been shown to play a role in epigenetic regulation. DNA methylation is a key regulator in epigenetic modification during mammalian cell development and differentiation. In mouse models, excess levels of SAM-e has been implicated in erroneous methylation patterns associated with diabetic neuropathy. SAM-e serves as the methyl donor in cytosine methylation, which is a key epigenetic regulatory process. Because of this impact on epigenetic regulation, SAM-e has been tested as an anti-cancer treatment. Cancer cell proliferation is dependent on having low levels of DNA methylation. In vitro addition has been shown to remethylate promoter sequences and decrease the production of proto-oncogenes.

Deficiencies in radical SAM-e enzymes have been associated with a variety of diseases including congenital heart disease, amyotrophic lateral sclerosis, and increased viral susceptibility.

Interactions and contraindications

Taking SAM at the same time as some drugs may increase the risk of serotonin syndrome, a potentially dangerous condition caused by having too much serotonin. These drugs include dextromethorphan (Robitussin), meperidine (Demerol), pentazocine (Talwin), and tramadol (Ultram). SAM may also interact with antidepressant medications increasing the potential for their side effects and reduce the effectiveness of levodopa for Parkinson's disease.[medical citation needed]

People who have bipolar disorder should not use SAM because it increases the risk of manic episodes.

Availability in different countries

In the United States and Canada, SAM is sold as a dietary supplement under the marketing name SAM-e (also spelled SAME or SAMe; pronounced "sam ee" or "Sammy"[citation needed]); it was introduced in the US in 1999, after the Dietary Supplement Health and Education Act was passed in 1994.

It was introduced as a prescription drug in Italy in 1979, in Spain in 1985, and in Germany in 1989; as of 2012, it was marketed as a prescription drug in Russia, India, China, Italy, Germany, Vietnam, and Mexico.

Alternative names

 SAM-e, SAMe, SAM, S-adenosyl-L-methionine, AdoMet, ademetionine

Source Wikipedia

Drynaria fortunei - Gu-Sui-Bu - Benefits and Properties

Drynaria fortunei, commonly known in China as Gu-Sui-Bu, is a species of basket fern of the family Polypodiaceae. The plant is native to Eastern Asia, including eastern China. Preparations from the roots of Drynaria have been used in traditional Asian medicine for aiding in the healing of bone fractures and for treating rheumatoid arthritis. 
Excessive bone loss, known as osteopenia or osteoporosis, is characterised by an imbalance between the bone-destroying cells, osteoclasts, and bone-building cells, osteoblasts. Human and animal data showed that Drynaria inhibiting osteoclast function without entirely halting it, as bisphosphonate drugs (alendronate, risedronate, ibandronate etc.) do. It stimulates osteoblasts to produce more healthy bone tissue. In addition, Drynaria attracts mesenchymal stem cells to accelerate the damaged bone repair. Drynaria has been shown to provide anti-osteoporotic effects in female mammals following the loss of ovaries and in animals with experimental osteoporosis induced by rheumatoid arthritis.

In addition, Drynaria extract exhibits an anti-inflammatory activity, protect the kidney from renal failure and possess an anti-tumour activity against multiple myeloma. 

Potential indications for the use of Drynaria in humans include:

Osteopenia
Osteoporosis
Poor dental health
Periodontal gum disease
Prevention of bone loss in postmenopausal women and people with rheumatoid arthritis, diabetes and those who take steroids (prednisone) on a long-term basis
Inflammation and pain management in patients with rheumatoid arthritis and osteoarthritis
Adjunct therapy of multiple myeloma
Adjunct treatment of renal insufficiency

Potential side effects:

Dizziness and lightheadedness
Mild nausea
Gastrointestinal discomfort

Potential drug interactions:

Bisphosphonates (alendronate, risedronate, ibandronate etc)
Calcitonin
Denosumab (prolia)
Teriparatide (Forteo)
Coumadin

Contraindications:

Pregnancy
Lactation
Chronic anticoagulation therapy

Complementary natural products:

Biotin
Calcium Lactate
Indian Thorny Bamboo
Magnesium Malate
Strontium Citrate
Taurine
Vitamin D

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Super Greens Powder - 22+ Superfoods - Spirulina Chlorella Barley WheatGrass Etc

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Benefits of Peak Supps Super Greens- Our unique blend offers a rich source of vitamins & minerals- Produced with only the highest grade ingredients- Improved blend of 22 nutrient dense super foods- Helps boost energy levels and detoxify the body- Promotes a more alkaline state in the body

Peak Supps Super greens are a potent super food formula, packed with nutrient dense food sources. Our nutritional profile is designed to help boost energy levels, detoxify the digestive system with the finest and most naturally nutritious ingredients.

Super Greens have burst on to the sports nutrition scene as they are considered to be one of the best sources of vitamins, minerals, antioxidants, polyphenols, enzymes, co-factors, adaptogens and trace elements.

Great source of FibreIn order to maintain a healthy colon and allow proper bowel movement fibre must be consumed, many people don't get enough fibre. Super Greens are a great source of Fibre offering 1.8g of Fibre per 10g serving. On average, most people in the UK get about 18g of fibre a day. The NHS guidelines recommend aiming for at least 30g a day.

Greens can help to restore PH balance
The human body needs to maintain a balanced PH acid level, what you eat can affect this. Foods such as grains, dairy and protein are acidic. Greens supplements are alkaline, which in turn helps the body’s acid-base balance. When the body is in a less acidic state it makes it more difficult for bacteria and viruses to grow. Super Greens are essential for anyone with a busy training schedule, when the body goes into an acidic state from intense exercise. 

Timing is important when it comes to Super Greens & Exercise
Exercise promotes inflammation and oxidation in the body. This would lead you to believe taking Super Greens packed full of anti-oxidants, straight after training when free radicals are present, would be a good time to do so. Research shows that consuming antioxidants after training can actually reduce the body’s ability to build muscle; this is because of Reactive oxygen species (ROS). ROS can help encourage the muscles to grow by increasing cell activity in the muscles that rebuild and repair tissue. We would recommend taking Super Greens throughout the day, and not after training for optimum results.

Recommended IntakeAdd 250-350ml of water or fruit juice into our shaker, then add 5-10g of Super Greens, shake and consume.Use 1-3 times daily. 1 Heaped teaspoon = 5g

Ways to take Super Greens- Due to the natural earthy taste of Super Greens, we would recommend adding the ratio 1:1 parts Apple juice or the juice of your choice with water to begin with.- Super Greens can be added to yoghurt along with dried fruit and nuts as a morning boost.- Super Greens can be added to a smoothie of your choice.
Full Ingredients list (Amount per 100g)Soya Lecithin Powder - 27.1gSpirulina Powder - 18.5gApple Fibre Powder - 7.8gBarley Grass Powder - 7.8gWheat Grass Powder - 7.8gOat Flour Powder - 7.8gAlfalfa Grass Powder - 6.5gChlorella (Broken Cell Wall) - 5.1g Soya Flour Powder - 2.8gAcerola Berry - 2.5gBeetroot Powder - 1.5gPomegranate Powder - 0.8g Siberian Ginseng - 0.5gCarrot Powder - 0.4gTomato Powder - 0.4gAstragalus Root Powder - 0.4gBroccoli Powder - 0.4gSpinach Powder - 0.4gGingko Biloba Extract 24/6 (50:1) - 0.3gGreen Tea 45% ECGC (95% Polyphenols) - 0.3g Grape Seed Extract (95% Polyphenols) - 0.2gElderberry Powder - 0.1gBilberry Fruit Powder - 0.1g
Nutritional Information (Per 10g Serving)Energy - 34Kcal / 142KjFat - 0.4g- Of which Saturates - 0.1gCarbohydrate - 4.3g- Of which Sugars - 1.2gFibre - 1.8gProtein - 2.4gSalt - 89mg
Allergens
Cereals containing GLUTEN - Barley Grass, Wheatgrass, Oat Flour (Possible contamination).SOYA - Soya Lecithin, Soya Flour. Sulphur Dioxide & Sulphites - Apple fibre powder 10mg/kg (Approx 23.4ppm). 
Serving SizesBelow is a guide on the number of servings in each Super Greens size:100g = 10-20 Servings (Based oAn 5-10g each serving)250g = 25-50 Servings500g = 50-100 Servings1kg   = 100-200 Servings

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Most Powerful Natural Anti-fungal Supplements and Herbs for Ridding the Body of Yeast

. 1. Caprylic Acid

This natural antifungal extract of the coconut palm destroys candida effectively.

Caprylic acid mimics the fatty acids produced by normal bowel flora, which are a significant factor in the body’s control over Candida. It has been successfully used in a time-release form that allows its release in the lower intestinal tract, as a treatment for those with severe intestinal candida. However, if not used in a time-release form, caprylic acid is less effective, as it is absorbed in the upper intestinal region. Caprylic acid is a natural candida treatment preferable over common antifungal drugs such as nystatin, which is itself yeast-based. Research at Wayne State University in Detroit shows that when nystatin treatment is stopped, even more, colonies of yeast develop than were present before its use. Caprylic acid has no such rebound effect once you stop using it after candida is under control.

Caprylic acid is now widely available at health-food stores and some pharmacies. The suggested dosage varies, but good results treating candida have been obtained by using 1000 to 2000 mg of time-release capsules three times a day with meals. It is an alternative to using oil of oregano.

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2. Undecylenic Acid (Calcium Undecylenate)

This is a safe and useful broad-spectrum natural antifungal supplement, a fatty acid extracted from castor bean oil. Its action is similar to, and usually more potent than, that of caprylic acid for treating candida. Undecylenic acid is a significant ingredient of combination formulations that also contain caprylic acid and other antifungal herbs such as pau d’arco. As with caprylic acid, it is important to use time-release capsules of undecylenic acid to avoid it being absorbed too high up in the gastrointestinal tract, thereby not reaching its targets.

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3. Garlic

Garlic has been the subject of worldwide research. Studies have proved its long-reputed antimicrobial and antifungal properties, as well as its action against Salmonella typhimurium and Escherichia coli, two extremely active microorganisms. Garlic is extremely effective against yeast and fungi. It can easily be incorporated into one’s diet as a natural remedy for candida, used as a seasoning on cooked vegetables, or crushed into salads. Or you can simply eat the raw cloves or use it with fish or poultry as many Greeks do.

The suggested dosage is 400 to 600 mg three times a day with food (supplements should contain approximately 4000 mcg of allicin per capsule) or one clove of fresh garlic daily.

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4. Berberine

Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. This natural antifungal compound is found in such plants as Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), Berberis aristata (tree turmeric), Hydrastis canadensis (goldenseal), Xanthorhiza simplicissima (yellowroot), Phellodendron amurense (Amur cork tree), Coptis chinensis (Chinese goldthread), Tinospora cordifolia (heartleaved moonseed), Argemone mexicana (prickly poppy), and Eschscholzia californica (California poppy).

Berberine has a wide spectrum of antibiotic activity against bacteria, protozoa, and fungi. Berberine’s action against Candida albicans has been shown to be more powerful than most medical drugs commonly used for these pathogens.

It has been shown to deactivate not only Candida albicans but ten other fungal species.

Berberine’s action against candida prevents its overgrowth after antibiotic use and also helps to repopulate the gut with friendly bacteria. In addition to being able to destroy bacteria, yeasts, and viruses, the naturally antifungal herbal compound berberine is also an antidiarrhea agent with immune-enhancing capabilities.

Suggested dosages as a herbal antifungal treatment for candida include three different options:

+ 1 to 2 g of dried bark or root of Berberis vulgaris or Hydrastis canadensis (powdered or as a tea) three times daily; or

+ 1 to 11⁄2 teaspoons (4 to 6 ml) of a tincture of either of these plants (diluted 1:5), three times daily; or

+ 1⁄4 to 1⁄2 teaspoon of a fluid extract of either of these plants, three times daily.

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5. Echinacea angustifolia (Purple Coneflower)

Purple coneflower, a North American plant species in the sunflower family, is a Native American antifungal herb that offers benefits similar to those of berberine in that it is a powerful antiviral and antifungal agent and an immune-system enhancer.

Some products combine echinacea, hydrastis, and berberine together with other immune-enhancing nutrients, such as zinc and vitamin C as a powerful anti candida supplement.

The dosage recommendations for encapsulated products is 750 to 1500 mg daily in divided doses.

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6. Horopito

The New Zealand plant of the Pseudowintera genus, commonly known as horopito, is the principal ingredient of Kolorex. This very slow-growing shrub has leaves that contain a strong natural antifungal agent, polygodial, which is a particularly effective remedy against Candida albicans. Studies have found that polygodial compares favorably with the powerful pharmaceutical antifungal amphotericin B. A study that tested eighty-two women with recurring vulvovaginal candidiasis over a period of twelve months found that horopito is “a natural antifungal phytocompound [that] proves to be as good as itraconazole in the maintenance treatment of RVVC [recurring vulvo-vaginal candidiasis].”

The recommended dosage for treating candida is one capsule containing approximately 350 mg daily of polygodial taken at the same time as 450 mg of anise seed (one capsule of each).

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7. Saccharomyces boulardii

Saccharomyces boulardii is a powerful antifungal yeast supplement derived from the lychee and mangosteen fruit, and it is used as a probiotic for candida and to re-introduce friendly bacteria into the gut. It is recommended for all anticandida treatment programs. The recommended dose is 250 mg twice daily. It should be noted, however, that in some severely immunocompromised individuals, S. boulardii has been associated with fungemia, or localized infection, which may be fatal.

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8. Grape Seed Extract

Grape seed extract is a proven antibacterial, antiviral, antiparasitic, and antifungal agent, with a high success rate for eliminating candida. In one study it was found that “GSE alone inhibited the growth of C. albicans yeast cells, and that in a murine model of disseminated candidiasis, mice groups given GSE before intravenous inoculation with the yeast cells survived longer than diluent-received (control) mice groups (P<0.05). This GSE antifungal effect was dose-dependent.”

As part of an anticandida supplementation program between 100 and 200 mg daily is recommended.

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9. Oil of Oregano

The essential oil of oregano contains powerful natural antifungal compounds. Side effects are minimal, although allergic reactions to oregano oil can occur, therefore you should stop taking oregano oil if allergic signs or symptoms appear. This is one of the most useful natural antifungal herbs and is widely available.

One study found that “both the oregano and Mexican oregano essential oils showed high levels of antifungal activity against… fluconazole-susceptible C. glabrata” subjects.

If possible, oregano oil should be taken in an entericcoated capsule, which delays its release until it reaches the intestinal tract. The recommended dosage for treating candida is 0.2 to 0.4 ml of an enteric-coated capsule twice a day between meals as an alternative to caprylic acid or calcium undecylenate.

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10. Pau d’Arco

The inner bark of a South American tree of the Tabebuia genus has a long history of folk use in the treatment of a wide variety of afflictions. Researchers have shown that pau d’arco extracts (containing lapachol) have strong antifungal actions and are particularly effective against Candida albicans. Pau d’arco is a naturally antifungal herb commonly taken in the form of tea, consumed several times daily.

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11. Aloe Vera

The juice of this desert plant is a powerful natural antifungal herbal agent.

The healing qualities of aloe vera have been known since Phoenician times. In recent years, attention has been drawn to its usefulness in a range of digestive conditions. Jeffrey Bland, a widely recognized authority in the nutritional medicine field, has demonstrated that the activity of the fresh juice on candida can help sufferers. In a study published in Preventive Medicine he says:

The effect of Aloe vera juice supplementation appeared to be that of altering colonic biota. Those subjects that had a heavy overgrowth of faecal bacteria and some yeast infection were found to have improved faecal colonisation and decreased yeast after the Aloe vera juice supplementation. This may indicate that the Aloe vera contains an agent or agents which are mycostatic or bacteriostatic or that the improved gastrointestinal function and altered pH of the bowel as it relates to Aloe vera juice supplementation sets the stage for different populations of [friendly] bacteria to flourish in the gut.

Aloe vera juice has a similar effect on bacterial and fungal infections of the skin, and it can be applied locally. One or two teaspoonfuls of aloe vera juice in water should be taken twice daily by anyone with candida problems as a natural antifungal supplement. (Note: once opened, aloe vera juice should be kept refrigerated. The optimum shelf life after opening is about one month.)

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12. Tea Tree Oil

This remarkable extract of the Australian plant Melaleuca alternifolia has powerful natural antifungal properties. Douching daily with a 1 percent solution in water (or, once a week, soaking a tampon into such a solution and inserting it into the vagina as a pessary, leaving it there for no more than 24 hours) can be very helpful as a natural treatment for vaginitis or cervicitis. This approach is useful whether the cause is candida or trichomonas. Tea tree oil can also be used as a gargle or mouthwash (one drop in a tumbler of water) for oral thrush or applied directly onto the skin as an ointment. It is somewhat irritating to the skin if used neat as an oil, but there are many products with a 15 percent tea-tree-oil content that is relatively nonirritating and are great antifungal supplements.

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13. Chamomile

The plant known as Matricaria chamomilla contains antifungal substances in its oil extract. Used as a tea or for topical application, it has soothing qualities similar to pau d’arco and can be a more mild remedy for candida.

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14. Tannate Plant Extracts

Plant extracts called tannates (such as the tannin in tea) are powerful natural antifungal agents. When taken orally, they destroy yeasts selectively, including their spores, without harming the natural flora of the body. There are also formulations for use in the mouth when candida is locally active, and for intravaginal use when thrush is evident. An advantage of using tannates as a herbal antifungal treatment for candida is that they act only in the digestive tract and are not absorbed at all elsewhere, unlike fatty acids, which may be absorbed too high up in the digestive tract unless delivered in suitable time-release capsules.

Additionally, tannates are also useful for detoxifying heavy metals from the body and are therefore suitable for use when mercury toxicity, for example, is a factor in immunosuppression.

Up to six (but usually three) capsules of 600 mg each of tannate products are suggested with every meal for up to eight weeks for naturally treating chronic candidiasis. Avoid taking tannate tablets on an empty stomach.

15. Antiparasitic Herb and Plant Extracts

Extracts of citrus (usually grapefruit) seeds have been promoted as safe, natural anticandida and antiparasitic agents. In one Polish study researchers concluded, “that 33% grapefruit extract exerts a potent antifungal activity against the yeastlike fungi strains [i.e., candida] and had low activity against dermatophytes and moulds.”

Additional antiparasitic herbal assistance is found with berberine (see above) and also Artemisia annua, a traditional Chinese herb (not to be confused with Artemisia absinthum, a traditional European herb that can be toxic and is illegal in some countries) that is commonly combined with grapefruit seed extract as a naturally antifungal and antiparasitic medicine. A number of safe, antiparasitic herbal combinations are available at health-food stores. Most are effective treatments against both yeasts and parasites, such as combinations of antifungal herbs like berberine, artemisia, and grapefruit seed extract.

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16. Biotin

Biotin, a water-soluble B vitamin (vitamin B7) that acts as a natural antifungal supplement, is an important nutrient that combats candida activity when taken with probiotic supplementation. One study showed that biotin inhibits the formation of hyphae, the branching filaments produced by candida species that can penetrate soft tissue (and may cause the leaky gut syndrome in the case of intestinal candida).

Biotin deficiency produces a number of skin conditions, including a dermatitis that is characterised by a greyish, dry, flaky appearance. This is accompanied by a lack of appetite, nausea, lassitude, and muscle pain. It is noteworthy that all of these symptoms are also commonly seen when candida proliferates, and it is worth questioning whether the supposed symptoms of biotin deficiency are not at least in part the result of the candida activity brought about by the deficiency.

Egg whites contain a substance called avidin, which is capable of combining with biotin, thus neutralising its usefulness in the body. For this reason, raw egg should not be included in the anticandida diet and supplementation protocol (although avidin is destroyed by cooking, so cooked eggs are ok).

Biotin should be taken as an antifungal supplement three times daily (between meals) in doses of 350 to 500 mcg, in association with Lactobacillus acidophilus.

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17. Olive Oil

Olive oil is a further natural antifungal aid in the prevention of the transformation of candida to its mycelial form. Olive oil contains oleic acid, which acts on the yeast in a similar way as biotin, making it an excellent natural antifungal supplement. The recommended amount of olive oil is six teaspoons daily, divided into three doses. This can be included in the meal (added to a salad or cooked vegetables) or taken before or after meals as desired. Ensure that the olive oil is virgin, coldpressed, and organic.

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