Thursday, 22 August 2019

Knee Pillow Orthopaedic Leg Cushion for Side Sleepers Back Sciatica Pain Relief - Tried and Tested

I can recommend this as I have been using this at night for the last three months, and my knee pain has dramatically reduced. It is very comfortable and stays in place. 




1.REDUCE BACK, HIP, LEG, KNEE & SCIATICA NERVE DISCOMFORT- As a side sleeper, you don’t sleep perfectly straight. Your top leg drops in front of you putting pressure on your back, your hip joints twist & your knees touch, causing pain. The Contour Pillow is the best leg pillow cushion for those looking for relief as the cushion comfortably supports your legs & knees to provide proper sleeping alignment & positioning to eliminate those painful pressure points.

2.THE ONLY LEG PILLOW THAT SUPPORTS BOTH YOUR LEGS & KNEES – The leg pillow was invented to help reduce the pressure that occurs from bad sleeping posture which causes discomfort. Years later we realized that cushioning & supporting BOTH your legs & knees are important in maintaining proper alignment to help reduce pain

3.VENTILATED MEMORY FOAM ALLOWS AIR TO CIRCULATE FOR A COOLER NIGHTS SLEEP – Unlike traditional memory foam leg pillow that are designed to absorb your body heat in order to compress, the designed with ventilated air holes in the memory foam that promote air circulation throughout the night. The temperature regulating foam technology pushes the heat outwards away from your body, to prevent you from feeling like you are overheating.

4.SLEEP COMFORTABLY IN ANY POSITION & MOVE FREELY THROUGH THE NIGHT – Unlike tradition knee pillows, features a true ergonomic design with its soft curves & crescent shape to fit men & women comfortably. Without requiring hazardous, circulation restricting straps, the precise tether of the pillow contours to fit the natural shape of your legs. This allows the foam leg pillow to contour to your shape without restricting movement or requiring you to sleep in a certain position.

5.USE 2 CONTOUR LEG PILLOWS FOR FULL & TOTAL LEG SUPPORT – For even better support and comfort, you can use 2 of the orthopedic pillows for total leg alignment & support & improved relief for your hips, lower legs & knees. The unique shape of this ergonomic contour leg pillow allows to fit for leg pillow comfort, but then you can change it, and place it between your calves for lower 




Sunday, 12 May 2019

Wild Garlic

Wild garlic guide: where to find, how to cook it and recipe ideas.

Late spring is the perfect times to go foraging for this versatile and pungent plant, which can be whipped up into a delicious soup or pesto. Our expert guide on where to find it and forage responsibly, how to cook it and tasty wild garlic recipe ideas

Wild garlic growing wild

Wild garlic facts

The plant, native to Britain, is also known as Bear leek, Bear’s garlic, Broad-leaved garlic, Buckrams, Ramsons, Wood garlic and can grow to heights of between 45 and 50 cm.
The leaves and flowers are edible. Young leaves are delicious added to soups, sauces and pesto. Leaves appear in March and are best picked when young. The flowers emerge from April to June and can add a potent garlic punch to salads and sandwiches.

Health benefits of wild garlic

Used traditionally throughout Europe as a spring tonic due to its blood-purifying properties, similarly to bulb garlic, wild garlic is also thought to lower cholesterol and blood-pressure, which in turn helps to reduce the risk of diseases such as heart attack or stroke.

Other uses for wild garlic

The leaves were once boiled and the resulting liquid used as a disinfectant. Its smell is said to repel cats, so may be a good inclusion for a keen ornithologist’s garden. Despite its strong scent, wild garlic has a much mellower taste than conventional garlic. Easily confused, prior to flowering, with the similarly leaved Lily of the Valley. Best not to eat this one though, it’s poisonous.

Where to find wild garlic

Dense clusters of green spears thrust from the woodland floor in spring: these are ramsons, better known as wild garlic and they are a sign that the woodland you are walking in is very old.
wild garlic flowers and leaves
Allium ursinum (WILD GARLIC, Ramson) in bloom, close-up/Credit: Getty
Closely related to onions and garlic, ramsons similarly grow from bulbs and give off a strong and attractive garlic smell. In continental Europe, the bulbs are thought to be a favourite food of brown bears, hence the plant’s scientific name Allium ursinum (bear leek).
Wild garlic likes damp ground where it will grow in abundance, with hundreds of green leaves growing on a single green stem. Here is a small selection of some of the best places to see, and to smell wild garlic in the UK:
Wild garlic thrives in woodlands
Wild garlic in Cotswolds' wood

What to do with wild garlic

Like the domesticated alliums, ramsons are edible and the leaves are an excellent addition to a cheese or pate sandwich. Dig up the bulbs and use like garlic, and save the flowers- they make a beautiful edible decoration to savoury dishes.
Whizzed up with walnuts, olive oil and a few tablespoons of parmesan added after, the leaves also make a delicious wild garlic pesto.
Better still, you can create a lovely spring soup from the leaves. Fry an onion in butter until soft and add a finely cubed potato and a bay leaf. After another five minutes frying, add 500ml of vegetable stock and simmer until the potato is soft –about 10 minutes. Add the bunch of ramsons leaves and cook briefly – no more than a couple of minutes. Remove the bay leaf, blend the soup, add seasoning and you will have a bowl of spring green goodness.

Wild garlic recipe ideas

River Cottage chef Gill Meller has created three delicious wild garlic recipes to rustle up using your foraged finds
Gill Mello forages wild garlic
Cook up a wild garlic feast with River Cottage Gill Mellor’s easy recipes

Wild garlic, potato and chorizo tortilla

I really enjoy cooking through spring and early summer. It’s a pleasure, particularly if you’ve gone out and picked a little wild garlic beforehand, and this simple breakfast or lunch dish is no exception. Big flavours and easy to find ingredients make it a pretty, reliable, no-hassle fallback.
Wild garlic, potato and chorizo tortilla
Wild garlic, potato and chorizo tortilla

Tuesday, 16 April 2019

Health benefits of bananas


Health benefits of bananas

​​1. ​Bananas are one of the best fruit sources of vitamin B6​

Vitamin B6 from bananas is easily absorbed by your body and a medium-sized banana can provide about a quarter of your daily vitamin B6 needs.
Vitamin B6 helps your body:
  • produce red blood cells,
  • metabolise carbohydrates and fats, turning them into energy,
  • metabolise amino acids,
  • remove unwanted chemicals from your liver and kidneys, and
  • maintain a healthy nervous system.
Vitamin B6 is also good for pregnant women as it helps meet their baby’s development needs.

2. Bananas are respectable sources of vitamin C

You may not associate bananas with vitamin C but a medium-sized banana will provide about 10% of your daily vitamin C needs.
Vitamin C helps:
  • protect your body against cell and tissue damage,
  • your body absorb iron better,
  • your body produce collagen - the protein which holds your skin, bones and body together, and
  • support brain health by producing serotonin, a hormone that affects our sleep cycle, moods, and experiences of stress a​nd pain.

3. Manganese in bananas is good for your skin

One medium-sized banana provides approximately 13% of your daily manganese needs. Manganese helps your body make collagen and protects your skin and other cells against free radical damage.

4. Potassium in bananas is good for your heart health and blood pressure

A medium-sized banana will provide around 320-400 mg of potassium, which meets about 10% of your daily potassium needs.
Potassium helps your body maintain a healthy heart and blood pressure. In addition, bananas are low in sodium. The low sodium and high potassium combination helps to control high blood pressure.

5. Bananas can aid digestion and help beat gastrointestinal issues

A medium banana will provide about 10-12% of your daily fibre needs. Singapore’s Health Promotion Board recommends a daily dietary fibre intake of 20g for women and 26g for men.
Soluble and insoluble fibres play an important role in your health. Soluble fibre helps your body control your blood sugar level and get rid of fatty substances such as cholesterol. Insoluble fibre adds weight and softness to stools, making it easier for you to have regular bowel movements. This helps to keep your gut healthy and safe from harmful bacteria.
Bananas, especially newly-ripened ones, contain starch that does not digest (resistant starch) in your small intestine and is able to pass into the large intestine. Such bananas help you manage your weight better as you stay full for longer.
That said, bananas can help you beat gastrointestinal issues such as:
  • constipation,
  • stomach ulcers, and
  • heartburn

6. Bananas give you energy – minus the fats and cholesterol​

Bananas contain three natural sugars – sucrose, fructose and glucose – giving you a fat and cholesterol-free source of energy. As such, bananas are ideal, especially for children and athletes, for breakfast, as a midday snack or before and after sports.


Friday, 22 March 2019

Himalayan Pink Salt 1kg - Pure and Naturally Organic Food Grade Fine Salt 1KG - £3.80 - Free Delivery

Himalayan Pink Salt Food Grade – Fine Crystals Our Himalayan Pink Salt comes from a salt range located 300km from the Himalayas; its Kosher, Halal and Suitable for Food Use. Our Himalayan Pink Salt Contains 84 trace minerals vital for well-being and a healthy Lifestyle.


What is Himalayan Pink Salt?
Himalayan Pink Salt was formed from ancient water beds millions of years ago which were covered with lava during the formation of the Himalayas. This salt has been insulated from the outside world for a long time and therefore has not picked up any impurities except beneficial minerals and elements from the surrounding rock formation.

How will Himalayan Pink Salt Benefit Me?

1. Sharpen vital brain functions and improve mental clarity.

   2. Increases hydration, Lowers blood pressure and Improves circulation.

3. Helps Prevent muscle cramping, Helps the intestines absorb nutrients and Strengthen bones.

 4. Anti-ageing Effects; rids the body of acidic wastes that cause skin degeneration.




Tuesday, 12 February 2019

PQQ benefits - Pyrroloquinoline Quinone - Mitochondrial Biogenesis

PQQ benefits and how they help the brain

Have you been looking for a supplement to combat ageing? Well PQQ may be it. Scientists found out about this compound only 50 years ago. There have been several health studies conducted about the potential benefits it provides the human body, the brain in particular.


What is PQQ?
PQQ is like a bodyguard to a man’s brain. PQQ is the acronym for pyrroloquinoline quinone. It is a compound found naturally in breast milk, soil, and certain foods. Pyrroloquinoline quinone PQQ helps the mitochondria (the powerhouse of the cells) thrive and continue to give us good health and longevity. According to researchers, PQQ provides neuroprotection, aiding in the formation of new mitochondria cells in the brain. This is very important if you wish to fight ageing issues such as loss of cognitive abilities and decreased energy levels.
Health benefits of PQQ pyrroloquinoline quinone
Here are the 13 health benefits that PQQ may provide you.
Treats obesity
PQQ may be a feasible weight loss solution. A study using rats showed that a diet deficient of PQQ reduced their metabolism by 10 per cent. Another study conducted on obese infant mice discovered that supplementing with PQQ increased their metabolism, reduced body fat, and may prevent nonalcoholic fatty liver disease. To further validate PQQ as an effective remedy against obesity, research on humans needs to be conducted.

Relieves inflammation
Inflammation opens the floodgate to slew of health problems, including accelerated ageing and neurological problems. Chronic inflammation in the brain is common to many neurodegenerative ailments such as Alzheimer’s disease and stroke.  PQQ may be able to combat this problem. Research shows that individuals who supplement with PQQ are protected against brain inflammation. Another study conducted on animals showed that PQQ has the ability to protect against inflammation may decrease the effects of traumatic brain injuries (e.g., concussion).

Enhances brain function
One of the main benefits of this compound is how much it enhances brain functionality. It stimulates the production and release of brand-new nerve cells (called nerve growth factor) that assist in neural tasks. These nerve cells communicate with each other to ensure that organs and other bodily functions are running smoothly. Studies appear to show that PQQ improves the memory, thinking, learning, and other cognitive abilities in ageing adults. In addition, research shows that PQQ has the ability to heal and rejuvenate damaged nerve cells, particularly in the brain.

Reduces oxidative stress
Oxidative stress can cause many different diseases – cancer, brain disorders, diabetes, heart problems, and more. This happens when an imbalance between free radicals and antioxidant defense occurs; a problem worsened by aging. PQQ helps boost the production of DJ-1, a protein that supports healthy brain function. This protein fights off oxidative stress by enhancing cell function and survival. In addition, PQQ protects new nerve cells from oxidative damage. This allows these nerve cells to survive and be able to potentially form new brain cells.

May extend lifespan
This compound may be able to improve your longevity. As one gets older, the brain suffers from multiple sources of damage. As the damage accumulates over time, this usually leads to the formation of brain disorders and chronic diseases such as stroke. Supplementing with PQQ may help guard against these neurological issues, especially as one gets older. And a big reason for this is because of its support of the mitochondria. Research shows that PQQ aids in the creation of new mitochondrial content. This increases longevity as well as improve energy utilisation and protection from free radicals.

Promotes mitochondrial function
Piggybacking off the last benefit, PQQ is a big proponent of the mitochondria. It aids and supports the mitochondria by promoting new content as well as improving the function of the current mitochondria. The mitochondria are responsible for transforming the food we eat into the energy needed to power our cells. This allows our cells to perform at peak function. Aiding the mitochondria promotes longevity and reducing the onset of age-related diseases. A human study showed that supplementing with PQQ rejuvenates mitochondrial function and restore new mitochondrial numbers. The study also showed improvements in the participants’ urinary oxidant levels, an indicator that the mitochondria are performing well.

Decreases cholesterol
Cholesterol is a waxy substance that’s found in all the cells in your body. Your body needs some cholesterol to serve a lot of functions, including the creation of Vitamin D and hormones. The problem lies when a man has too much cholesterol. High cholesterol clogs up blood vessels, making the heart work harder to perform its daily tasks. Ultimately, this may lead to a heart attack and/or a stroke. PQQ may help regulate cholesterol levels. A Japanese study showed that individuals who supplemented with PQQ disodium salt lowered their bad LDL cholesterol levels.

Improves sleep, mood, and fatigue
Millions of men don’t get enough sleep on a nightly basis. Poor sleep quality is linked to a slew of chronic diseases such as stroke. In addition, a lack of sleep negatively affects your mood and causes fatigue throughout the day. PQQ may be what you need if you have had issues getting good quality sleep. A 2-month research study showed that individuals who used PQQ improved overall sleep quality. They were able to fall asleep with no issues and slept longer. Also, the subjects showed significant improvements in their mood and energy levels.

Improves memory and reasoning
The biggest issue most men face as they get older is the loss of cognitive function. According to the Alzheimer’s Association, men are at greater risk of developing age-related cognitive deficiencies that often cause memory loss and the inability to think clearly. Several studies point out how PQQ could reverse this trend. PQQ may prevent brain decline that stems from ageing. Human and animal studies demonstrate its ability to improve one’s memory and reasoning skills. The main reason for this is due to PQQ’s ability to trigger mitochondrial growth and reduce oxidative stress.

Protects your heart from stroke
According to the CDC, heart disease is the leading cause of death for both men and women. More than half of the deaths due to heart disease in 2015 were in men. PQQ may be able to curtail those statistics. An animal study showed that PQQ improves cardiac functions and reduce damages for heart attack sufferers. And these benefits can happen when PQQ is taken before or after the heart attack occurred.

Another study compared the effects of PQQ to standard heart attack medicine (metoprolol). Both reduced the size of the damaged areas and protected against further trauma. However, PQQ did a better job of reducing cellular damage. This led researchers to deem the compound as the superior medicine to protect the heart against oxidative stress. Further evidence has shown that PQQ is highly effective at supporting mitochondrial function within the heart cells.

Decreases insulin resistance
Insulin resistance interferes with our ability to effectively regulate our sugar intake. This can lead to health problems such as diabetes, metabolic syndrome, and obesity. Similar to exercise, PQQ reduces insulin resistance by boosting mitochondrial activity in muscle cells. The compound also inhibits, PTP1B, a protein that’s been shown to cause insulin resistance. (High levels of this protein is found in people suffering from breast cancer)

Improves immune health
It is widely known how essential it is to have an efficient immune system. An efficient immune system prevents the onset of chronic diseases and fights off inflammation. A study showed that mice lacking enough PQQ experienced poor immune function. In another mice study, increased intake of the compound boosted immune health. It did this by increasing levels of two vital immune regulators: CD8+ cells and lymphocytes.

PQQ is neuroprotective against Alzheimer’s disease, Parkinson’s, and cognitive injuries
One thing you definitely know by now is that PQQ is neuroprotective. This compound does a good job of protecting memory and cognitive skills. The worst diseases deriving from poor brain health is Alzheimer’s and Parkinson’s. Both diseases affect millions of people worldwide, the elderly in particular. PQQ may protect against the onset of Alzheimer’s Disease and Parkinson’s disease.

One study shows that it protects the brain against powerful toxins and proteins that are associated with these cognitive diseases. And the compound protects neurons from overstimulation, a condition called excitotoxicity. Excitotoxicity of the neurons is associated with seizures, schizophrenia, and other neurodegenerative diseases.

How to take PQQ
PQQ dosage
Here are the recommended dosage amounts for PQQ supplements:

To boost mitochondrial activity in your cells….0.075 to 0.3mg/kg per day
To decrease chronic inflammation in the average-size male….20mg per day

Food
Supplementation of PQQ is great. But to really maximise your exposure to the compound, your diet should consist of PQQ-rich natural food sources and plant-based foods. Here is a list of such foods:

Sweet Potato
Parsley
Egg Yolk
Cabbage
Natto
Papaya
Green Pepper
Carrot
Spinach
Fava Bean
Miso
Kiwi
Celery
Potato
Orange
Banana
Tomato
Green Peppers
PQQ supplement
After combing through a litany of online stores, here are five PQQ supplements that have gained a ton of favorable reviews. (Note: This is not a top five list.)

Doctor’s Best, Best PQQ, 20 mg, 30 Veggie Caps
Jarrow Formulas, Ubiquinol, QH+ PQQ, 30 Softgels
Swanson Ultra: PQQ Pyrroloquinoline Quinone
PQQ + CoQ10 – 60 Capsules – Oral Supplement for Cardiovascular and Mental Support by Dr’s Hope
PQQ 20mg (Pyrroloquinoline Quinone) 30 Vegecaps
PQQ side effects and dangers
As with any supplement, there is a likelihood of side effects. PPQ is no different. In one study, rats were given a dosage as high as 100mg/kg per day but experienced no side effects. However, some humans who took the compound experienced insomnia, mild headaches, and even energy crashes during the midday. The reason for these side effects could be that they either took too much or their body is sensitive to a direct dosage of pyrroloquinoline quinone.

Either way, it is wise to start off with a small dose (0.075mg) for at least one week. If you can handle that, feel free to slightly increase the dosage. It’s recommended that you don’t take no more than 20mg per day.

PQQ supplement may be the next best supplement for men
Protein powder and fish oils may have to make room for PQQ. This compound shows a lot of promise, especially for older men. PQQ may be the best anti-ageing supplement/nutrient that most guys don’t know about. Some who have supplemented with it felt that it immediately:

Improved their mood
Improved their focus and ability to remember things
Boosted their energy levels
Improved workout performance
And those are just the immediate benefits. Other benefits such as lower cholesterol and an improved immune system will obviously take time to manifest. Overall, pyrroloquinoline quinone is a substance that you should consider getting acquainted with as you get older.

Friday, 8 February 2019

SAMe Supplements Benefits and Use

- If you live with a condition like osteoarthritis or depression, you may already know how it can affect other aspects of your health, contributing to issues like weight gain, difficulty sleeping, and chronic pain.


One remedy said to ease depression, arthritis, and other conditions is the supplement SAMe, also known as SAM-e, ademetionine, or S-adenosylmethionine. SAMe is the synthetic form of a compound that is produced naturally in the body from methionine (an essential amino acid) and adenosine triphosphate (an energy-producing compound).

SAMe isn't found naturally in food. The body typically makes what it needs for good health, however, some disease states and low levels of methionine, folate, or vitamin B12 are believed to contribute to low levels of SAMe.

It's thought that SAMe can help promote the production of chemicals known to play a key role in a variety of processes in the body, such as mood regulation, immune function, and pain perception.
Why Do People Take SAMe Supplements?
SAMe is typically used for the following health issues:

Anxiety
Depression
Fibromyalgia
Osteoarthritis
Pain
Premenstrual syndrome (PMS)
SAMe is also said to enhance mental performance, boost liver health, slow the ageing process, and help people quit smoking.



The Benefits: Can It Really Help?
Here's a look at some of the research on the possible benefits of SAMe.

1) Osteoarthritis: SAMe shows promise in the treatment of osteoarthritis of the knee or hip. It is said to relieve pain and have anti-inflammatory properties, and some research suggests that it may promote cartilage repair.


In a report published in the Cochrane Database of Systematic Reviews in 2009, researchers analysed four previously published clinical trials (with a total of 656 participants) and found that the use of SAMe may help reduce pain and improve function in people with osteoarthritis. Since the reviewed trials were of poor quality, however, the review's authors deemed these findings inconclusive.

2) Depression: In a research review published in the Cochrane Database of Systematic Reviews in 2016, scientists analysed eight previously published clinical trials comparing SAMe to the antidepressants imipramine, desipramine, or escitalopram, or a placebo.


SAMe was superior to a placebo when used with selective serotonin reuptake inhibitor (SSRI) antidepressants, but the evidence was considered low quality. Compared to imipramine, fewer participants experienced adverse effects when treated with an injectable form of SAMe. SAMe wasn't different from the placebo or antidepressants such as imipramine or escitalopram when used alone.

In their conclusion, the review's authors state that the use of SAMe for depression needs to be investigated further in larger and better-planned trials "given the absence of high-quality evidence and the inability to draw firm conclusions based on that evidence."

3) Fibromyalgia: In a research review published in the Journal of Complementary and Alternative Medicine in 2010, scientists looked at 70 previously published clinical trials evaluating the use of various types of complementary therapies for chronic fatigue syndrome and fibromyalgia. Along with magnesium, L-carnitine, acupuncture, and several types of meditation practice, the review's authors named SAMe among the therapies with the most potential for further research on their effectiveness against these conditions.

4) Liver Disease: SAMe may improve liver function in people with chronic liver disease, suggests a research review published in the journal PLoS One in 2015. However, in evaluating the 12 previously published clinical trials included in the review, the authors also found that SAMe may of limited benefit in the treatment of certain liver conditions such as viral hepatitis and cholestasis.

Possible Side Effects
SAMe may trigger a number of side effects, including anxiety, constipation, diarrhea, dry mouth, headache, heartburn, insomnia, gas, low blood sugar, nausea, nervousness, skin rash, and vomiting. Large amounts of SAMe may cause mania (an abnormally elevated mood). There's also some concern that the use of SAMe can trigger an allergic reaction in some people. 

If you have bipolar disorder, Lesch-Nyhan syndrome, Parkinson's disease, or other health conditions, you should only use SAMe under the supervision of your healthcare provider as it may worsen symptoms. 

It's important to note that there may be risks when combining SAMe with medication or other supplements. You shouldn't take SAMe in combination with antidepressants, cough medicine, diabetes medication, levodopa (L-dopa), L-tryptophan, medication that affects serotonin levels, St. John's wort, or other medication unless you are being monitored by a health professional. SAMe should be discontinued at least two weeks before a scheduled surgery.

The safety of SAMe in children, pregnant or nursing women, or people with kidney or liver disease hasn't been established. You can get tips on using supplements safely, but you should speak with your primary care provider before taking SAMe to discuss whether it's appropriate for you. Keep in mind that SAMe shouldn't be used as a substitute for standard treatment.
Source - VeryWell   

And now the science bit
S-Adenosyl methionine[alternative names is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM-e is produced and consumed in the liver. More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase. SAM was first discovered by Giulio Cantoni in 1952.

In bacteria, SAM-e is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis. In eukaryotic cells, SAM-e serves as a regulator of a variety of processes including DNA, tRNA, and rRNA methylation; immune response; amino acid metabolism; transsulfuration; and more. In plants, SAM-e is crucial to the biosynthesis of ethylene, an important plant hormone and signaling molecule.

SAM-e cycle
The reactions that produce, consume, and regenerate SAM-e are called the SAM-e cycle. In the first step of this cycle, the SAM-dependent methylases  that use SAM-e as a substrate produce S-adenosyl homocysteine as a product. S-Adenosyl homocysteine is a strong negative regulator of nearly all SAM-dependent methylases despite their biological diversity. This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase and the homocysteine recycled back to methionine through transfer of a methyl group from 5-methyltetrahydrofolate, by one of the two classes of methionine synthases (i.e. cobalamin-dependent or cobalamin-independent. This methionine can then be converted back to SAM-e, completing the cycle. In the rate-limiting step of the SAM cycle, MTHFR (methylenetetrahydrofolate reductase) irreversibly reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate.

Radical SAM-e enzymes
A large number of iron-sulfur cluster-containing enzymes cleave SAM-e reductively to produce a 5′-deoxyadenosyl 5′-radical as an intermediate, and are called radical SAM enzymes. Most enzymes with this capability share a region of sequence homology that includes the motif CxxxCxxC or a close variant. The radical intermediate allows enzymes to perform a wide variety of unusual chemical reactions. Examples of radical SAM enzymes include spore photoproduct lyase, activases of pyruvate formate lyase and anaerobic sulfatases, lysine 2,3-aminomutase, and various enzymes of cofactor biosynthesis, peptide modification, metalloprotein cluster formation, tRNA modification, lipid metabolism, etc. Some radical SAM-e enzymes use a second SAM-e as a methyl donor. Radical SAM enzymes are much more abundant in anaerobic bacteria than in aerobic organisms. They can be found in all domains of life and are largely unexplored. A recent bioinformatics study concluded that this family of enzymes includes at least 114,000 sequences including 65 unique reactions.
Polyamine biosynthesis
Another major role of SAM-e is in polyamine biosynthesis. Here, SAM-e is decarboxylated by adenosylmethionine decarboxylase to form S-adenosylmethioninamine. This compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.

SAM-e is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and neurotransmitters that affect mood, such as epinephrine. Methyltransferases are also responsible for the addition of methyl groups to the 2′ hydroxyls of the first and second nucleotides next to the 5′ cap in messenger RNA.
As of 2012 the evidence was inconclusive as to whether SAM can mitigate the pain of osteoarthritis; clinical trials that had been conducted were too small from which to generalize. A 2016 study concluded that for major depressive disorder, "Given the absence of high-quality evidence and the inability to draw firm conclusions based on that evidence, the use of SAMe for the treatment of depression in adults should be investigated further."

The SAM-e cycle has been closely tied to the liver since 1947 because people with alcoholic cirrhosis of the liver would accumulate large amounts of methionine in their blood. While multiple lines of evidence from laboratory tests on cells and animal models suggest that SAM might be useful to treat various liver diseases, as of 2012 SAM had not been studied in any large randomized placebo-controlled clinical trials that would allow an assessment of its efficacy and safety.

Pharmacokinetics
Oral SAM achieves peak plasma concentrations three to five hours after ingestion of an enteric-coated tablet (400–1000 mg). The half-life is about 100 minutes.
Adverse effects
Gastrointestinal disorder, dyspepsia and anxiety can occur with SAM consumption. Long-term effects are unknown. SAM is a weak DNA-alkylating agent.

Another reported side effect of SAM is insomnia; therefore, the supplement is often taken in the morning. Other reports of mild side effects include lack of appetite, constipation, nausea, dry mouth, sweating, and anxiety/nervousness, but in placebo-controlled studies, these side effects occur at about the same incidence in the placebo groups.[medical citation needed]

SAM-e has recently been shown to play a role in epigenetic regulation. DNA methylation is a key regulator in epigenetic modification during mammalian cell development and differentiation. In mouse models, excess levels of SAM-e has been implicated in erroneous methylation patterns associated with diabetic neuropathy. SAM-e serves as the methyl donor in cytosine methylation, which is a key epigenetic regulatory process. Because of this impact on epigenetic regulation, SAM-e has been tested as an anti-cancer treatment. Cancer cell proliferation is dependent on having low levels of DNA methylation. In vitro addition has been shown to remethylate promoter sequences and decrease the production of proto-oncogenes.

Deficiencies in radical SAM-e enzymes have been associated with a variety of diseases including congenital heart disease, amyotrophic lateral sclerosis, and increased viral susceptibility.
Interactions and contraindications
Taking SAM at the same time as some drugs may increase the risk of serotonin syndrome, a potentially dangerous condition caused by having too much serotonin. These drugs include dextromethorphan (Robitussin), meperidine (Demerol), pentazocine (Talwin), and tramadol (Ultram). SAM may also interact with antidepressant medications increasing the potential for their side effects and reduce the effectiveness of levodopa for Parkinson's disease.[medical citation needed]

People who have bipolar disorder should not use SAM because it increases the risk of manic episodes.
Availability in different countries
In the United States and Canada, SAM is sold as a dietary supplement under the marketing name SAM-e (also spelled SAME or SAMe; pronounced "sam ee" or "Sammy"[citation needed]); it was introduced in the US in 1999, after the Dietary Supplement Health and Education Act was passed in 1994.

It was introduced as a prescription drug in Italy in 1979, in Spain in 1985, and in Germany in 1989; as of 2012, it was marketed as a prescription drug in Russia, India, China, Italy, Germany, Vietnam, and Mexico.
Alternative names
 SAM-e, SAMe, SAM, S-adenosyl-L-methionine, AdoMet, ademetionine
Source Wikipedia




Thursday, 7 February 2019

Drynaria fortunei - Gu-Sui-Bu - Benefits and Properties

Drynaria fortunei, commonly known in China as Gu-Sui-Bu, is a species of basket fern of the family Polypodiaceae. The plant is native to Eastern Asia, including eastern China. Preparations from the roots of Drynaria have been used in traditional Asian medicine for aiding in the healing of bone fractures and for treating rheumatoid arthritis. 
Excessive bone loss, known as osteopenia or osteoporosis, is characterised by an imbalance between the bone-destroying cells, osteoclasts, and bone-building cells, osteoblasts. Human and animal data showed that Drynaria inhibiting osteoclast function without entirely halting it, as bisphosphonate drugs (alendronate, risedronate, ibandronate etc.) do. It stimulates osteoblasts to produce more healthy bone tissue. In addition, Drynaria attracts mesenchymal stem cells to accelerate the damaged bone repair. Drynaria has been shown to provide anti-osteoporotic effects in female mammals following the loss of ovaries and in animals with experimental osteoporosis induced by rheumatoid arthritis.

In addition, Drynaria extract exhibits an anti-inflammatory activity, protect the kidney from renal failure and possess an anti-tumour activity against multiple myeloma. 

Potential indications for the use of Drynaria in humans include:

Osteopenia
Osteoporosis
Poor dental health
Periodontal gum disease
Prevention of bone loss in postmenopausal women and people with rheumatoid arthritis, diabetes and those who take steroids (prednisone) on a long-term basis
Inflammation and pain management in patients with rheumatoid arthritis and osteoarthritis
Adjunct therapy of multiple myeloma
Adjunct treatment of renal insufficiency

Potential side effects:

Dizziness and lightheadedness
Mild nausea
Gastrointestinal discomfort

Potential drug interactions:

Bisphosphonates (alendronate, risedronate, ibandronate etc)
Calcitonin
Denosumab (prolia)
Teriparatide (Forteo)
Coumadin

Contraindications:

Pregnancy
Lactation
Chronic anticoagulation therapy

Complementary natural products:

Biotin
Calcium Lactate
Indian Thorny Bamboo
Magnesium Malate
Strontium Citrate
Taurine
Vitamin D

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Thursday, 31 January 2019

Super Greens Powder - 22+ Superfoods - Spirulina Chlorella Barley WheatGrass Etc

- Sellers Comments
Benefits of Peak Supps Super Greens- Our unique blend offers a rich source of vitamins & minerals- Produced with only the highest grade ingredients- Improved blend of 22 nutrient dense super foods- Helps boost energy levels and detoxify the body- Promotes a more alkaline state in the body
Peak Supps Super greens are a potent super food formula, packed with nutrient dense food sources. Our nutritional profile is designed to help boost energy levels, detoxify the digestive system with the finest and most naturally nutritious ingredients.
Super Greens have burst on to the sports nutrition scene as they are considered to be one of the best sources of vitamins, minerals, antioxidants, polyphenols, enzymes, co-factors, adaptogens and trace elements.
Great source of FibreIn order to maintain a healthy colon and allow proper bowel movement fibre must be consumed, many people don't get enough fibre. Super Greens are a great source of Fibre offering 1.8g of Fibre per 10g serving. On average, most people in the UK get about 18g of fibre a day. The NHS guidelines recommend aiming for at least 30g a day.
Greens can help to restore PH balance
The human body needs to maintain a balanced PH acid level, what you eat can affect this. Foods such as grains, dairy and protein are acidic. Greens supplements are alkaline, which in turn helps the body’s acid-base balance. When the body is in a less acidic state it makes it more difficult for bacteria and viruses to grow. Super Greens are essential for anyone with a busy training schedule, when the body goes into an acidic state from intense exercise. 
Timing is important when it comes to Super Greens & Exercise
Exercise promotes inflammation and oxidation in the body. This would lead you to believe taking Super Greens packed full of anti-oxidants, straight after training when free radicals are present, would be a good time to do so. Research shows that consuming antioxidants after training can actually reduce the body’s ability to build muscle; this is because of Reactive oxygen species (ROS). ROS can help encourage the muscles to grow by increasing cell activity in the muscles that rebuild and repair tissue. We would recommend taking Super Greens throughout the day, and not after training for optimum results.
Recommended IntakeAdd 250-350ml of water or fruit juice into our shaker, then add 5-10g of Super Greens, shake and consume.Use 1-3 times daily. 1 Heaped teaspoon = 5g
Ways to take Super Greens- Due to the natural earthy taste of Super Greens, we would recommend adding the ratio 1:1 parts Apple juice or the juice of your choice with water to begin with.- Super Greens can be added to yoghurt along with dried fruit and nuts as a morning boost.- Super Greens can be added to a smoothie of your choice.
Full Ingredients list (Amount per 100g)
Soya Lecithin Powder - 27.1gSpirulina Powder - 18.5gApple Fibre Powder - 7.8gBarley Grass Powder - 7.8gWheat Grass Powder - 7.8gOat Flour Powder - 7.8gAlfalfa Grass Powder - 6.5gChlorella (Broken Cell Wall) - 5.1g Soya Flour Powder - 2.8gAcerola Berry - 2.5gBeetroot Powder - 1.5gPomegranate Powder - 0.8g Siberian Ginseng - 0.5gCarrot Powder - 0.4gTomato Powder - 0.4gAstragalus Root Powder - 0.4gBroccoli Powder - 0.4gSpinach Powder - 0.4gGingko Biloba Extract 24/6 (50:1) - 0.3gGreen Tea 45% ECGC (95% Polyphenols) - 0.3g Grape Seed Extract (95% Polyphenols) - 0.2gElderberry Powder - 0.1gBilberry Fruit Powder - 0.1g
Nutritional Information (Per 10g Serving)
Energy - 34Kcal / 142KjFat - 0.4g- Of which Saturates - 0.1gCarbohydrate - 4.3g- Of which Sugars - 1.2gFibre - 1.8gProtein - 2.4gSalt - 89mg
Allergens
Cereals containing GLUTEN - Barley Grass, Wheatgrass, Oat Flour (Possible contamination).SOYA - Soya Lecithin, Soya Flour. Sulphur Dioxide & Sulphites - Apple fibre powder 10mg/kg (Approx 23.4ppm). 
Serving Sizes
Below is a guide on the number of servings in each Super Greens size:100g = 10-20 Servings (Based oAn 5-10g each serving)250g = 25-50 Servings500g = 50-100 Servings1kg   = 100-200 Servings